{"id":1333,"date":"2025-05-08T15:07:11","date_gmt":"2025-05-08T13:07:11","guid":{"rendered":"https:\/\/c29ugbqilr.preview.infomaniak.website\/?post_type=portfolio&#038;p=1333"},"modified":"2025-05-20T13:13:02","modified_gmt":"2025-05-20T11:13:02","slug":"personalized-data-driven-prediction-and-assessment-of-infection-related-outcomes-in-swiss-icus-iicu","status":"publish","type":"portfolio","link":"https:\/\/spsp.ch\/fr\/portfolio\/personalized-data-driven-prediction-and-assessment-of-infection-related-outcomes-in-swiss-icus-iicu\/","title":{"rendered":"Personalized, data-driven prediction and assessment of Infection related outcomes in Swiss ICUs (IICU)"},"content":{"rendered":"<p>Infections show a range of endo- and phenotypes with variable impact on <strong>clinical course and outcomes<\/strong>. To account for heterogeneity in a data-driven manner and thereby, achieve <strong>personalized assessment, characterization and outcome prediction<\/strong>, clinical data warehouses (CDWH), and our driver project <a href=\"https:\/\/sepsis-network.ch\/\" target=\"_blank\" rel=\"noopener\">Personalized Swiss Sepsis Study (PSSS)<\/a> enabled major advancements in accessing, collecting, and structuring data on host, pathogen characteristics, and temporal developments. During PSSS, it became evident that <strong>two key data gaps remain<\/strong>: a) lack of clinical context and b) missing interpretation of clinical phenotypes. Profound understanding \u201cwhich intervention was done and for what reason\u201d is critical for patient management. Therefore, we will develop <strong>harmonized clinical annotation<\/strong> for infections and outcomes, as well as for <strong>infection-related context and interpretation.<\/strong> The resulting data will enable contextual data from clinical experts and data-driven approaches for patient assessment, characterization, and outcome prediction. <strong>Our approach will revolutionize prediction of infection-related outcomes on intensive care units (ICUs).<br \/>\n<\/strong><\/p>\n<p><strong>First goal:<\/strong> <strong>Maintain the PSSS platform and expand<\/strong> beyond sepsis to other infections, ensuring F<strong>AIR principles and collaborations<\/strong>.<\/p>\n<p><strong>Second goal:<\/strong> <strong>Focus on data quality<\/strong> by harmonizing annotation of phenotypes, context, and interpretation with shared standardized definitions and ontologies.<\/p>\n<p><strong>Third goal:<\/strong> <strong>Form a sustainable network between ICUs, infectious diseases, microbiology, and data science.<\/strong> Improving accessibility of data and tools to promote research. Contemporaneously, forming a national and international research platform.<\/p>\n<p><strong>Fourth goal:<\/strong> Develop both clinical and data-driven procedures for <strong>rapid and precise assessment of patients<\/strong> exhibiting infection-related phenotypes. <strong>In-depth and multi-dimensional characterization<\/strong> of endo- and phenotypes including clinical presentation, -omics, and pathogen properties. <strong>Early prediction<\/strong> of outcomes, accounting for individual clinical context. Validation of digital biomarkers and evaluation of<strong> potential treatment implications<\/strong> e.g., focusing on antibiotic stewardship.<\/p>\n<p><strong>Fifth goal:<\/strong> <strong>Generation<\/strong> of a multicentric FAIR<strong> public data repository<\/strong> ready for 1st\/2nd\/3rd party use focusing on outcomes in ICUs, with <strong>software package<\/strong> for phenotype assessment, characterization, biomarker discovery, and retrospective clinical validation.<\/p>\n<p>Click <a href=\"https:\/\/sphn.ch\/wp-content\/uploads\/2022\/10\/NDS-2021-902_ExecutiveSummary.pdf\">here<\/a> to read the full executive summary.<\/p>","protected":false},"featured_media":3451,"menu_order":3,"template":"","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","_price":"","_stock":"","_tribe_ticket_header":"","_tribe_default_ticket_provider":"","_tribe_ticket_capacity":"0","_ticket_start_date":"","_ticket_end_date":"","_tribe_ticket_show_description":"","_tribe_ticket_show_not_going":false,"_tribe_ticket_use_global_stock":"","_tribe_ticket_global_stock_level":"","_global_stock_mode":"","_global_stock_cap":"","_tribe_rsvp_for_event":"","_tribe_ticket_going_count":"","_tribe_ticket_not_going_count":"","_tribe_tickets_list":"[]","_tribe_ticket_has_attendee_info_fields":false,"_links_to":"","_links_to_target":""},"portfolio-category":[23],"portfolio-tag":[],"class_list":["post-1333","portfolio","type-portfolio","status-publish","has-post-thumbnail","hentry","portfolio-category-bacteria"],"_links":{"self":[{"href":"https:\/\/spsp.ch\/fr\/wp-json\/wp\/v2\/portfolio\/1333","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spsp.ch\/fr\/wp-json\/wp\/v2\/portfolio"}],"about":[{"href":"https:\/\/spsp.ch\/fr\/wp-json\/wp\/v2\/types\/portfolio"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spsp.ch\/fr\/wp-json\/wp\/v2\/media\/3451"}],"wp:attachment":[{"href":"https:\/\/spsp.ch\/fr\/wp-json\/wp\/v2\/media?parent=1333"}],"wp:term":[{"taxonomy":"portfolio-category","embeddable":true,"href":"https:\/\/spsp.ch\/fr\/wp-json\/wp\/v2\/portfolio-category?post=1333"},{"taxonomy":"portfolio-tag","embeddable":true,"href":"https:\/\/spsp.ch\/fr\/wp-json\/wp\/v2\/portfolio-tag?post=1333"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}